trimetrexate

PubChem Notes:

Trimetrexate A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.

Molecular Formula: C19H23N5O3


InChI: InChI=1/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24)/f/h20-21H2

InChIKey: InChIKey=NOYPYLRCIDNJJB-WAVZXACUCZ
SMILES: CC1=C(C=CC2=C1C(=NC(=N2)N)N)CNC3=CC(=C(C(=C3)OC)OC)OC

Names:
    CI-898
    Jb-11
    NSC-249008
    TMQ
    trimetrexate
    5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]quinazoline-2,4-diamine

Registries:
    PubChem CID 5583
    PubChem ID 12012739