Nirulid

Amiloride A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)

Molecular Formula: C₆H₁₃Cl₂N₇O₃

InChI: InChI=1/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2/f/h8-11H2;;;

InChIKey: InChIKey=LTKVFMLMEYCWMK-QPNDJESQCC
SMILES: C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.O.O.Cl

Names:
    Amiloride hydrochloride dihydrate
    Amiloride hydrochloride [USAN]
    AMILORIDE HYDROCHLORIDE
    Amilorid hydrochlorid-2-wasser
    Frumil
    Midamor
    MK 870
    Modamide
    Moduretic
    Nirulid
    3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide dihydrate hydrochloride

Registries:
    PubChem CID 68540
    PubChem ID 210665