RIOPROSTIL

Rioprostil A synthetic methylprostaglandin E1 analog that reduces gastric acid secretion and enhances the gastric mucus-bicarbonate barrier. It is effective in the therapy of gastric ulcers and gives significant protection against NSAID-induced gastric mucosal damage. The drug also prevents cyclosporin A-induced damage to endocrine and exocrine pancreatic secretions. It shows a low order of acute toxicity and there is no evidence of embryotoxicity, fetotoxicity, teratogenicity, or mutagenicity in animal studies.

Molecular Formula: C₂₁H₃₈O₄

InChI: InChI=1/C21H38O4/c1-3-4-13-21(2,25)14-10-12-18-17(19(23)16-20(18)24)11-8-6-5-7-9-15-22/h10,12,17-18,20,22,24-25H,3-9,11,13-16H2,1-2H3/b12-10+/t17-,18-,20-,21?/m1/s1

InChIKey: InChIKey=SPOAFZKFCYREMW-FWYLUGOYBN
SMILES: CCCCC(C)(CC=CC1C(CC(=O)C1CCCCCCCO)O)O

Names:
    ORF 15927
    Prost-13-en-9-one, 1,11,16-trihydroxy-16-methyl-, (11alpha,13E)-
    Rioprostilo [Spanish]
    Rioprostilum [Latin]
    Rioprostil [USAN:BAN:INN]
    RIOPROSTIL
    RWJ 15927
    TR-4698
    (13E)-11alpha,16-Dihydroxy-16-methyl-9-oxo-13-prostenol
    (2R,3R,4R)-4-Hydroxy-2-(7-hydroxyheptyl)-3-((E)-(4RS)-(4-hydroxy-4-methyl-1-octenyl))cyclopentanone
    (2R,3S,4R)-4-hydroxy-2-(7-hydroxyheptyl)-3-[(E)-4-hydroxy-4-methyl-oct-1-enyl]cyclopentan-1-one

Registries:
    PubChem CID 5311413
    PubChem ID 191451