Tsiklomitsin

[(Science: drug) broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both gram-positive and gram-negative organisms (and those of organelles). Produced by streptomyces aureofasciens. Other exaples include tetracycline, demeclocycline and doxycycline.

[1. A broad spectrum antibiotic (a naphthacene derivative), the parent of oxytetracycline, prepared from chlortetracycline and also obtained from the culture filtrate of several species of Streptomyces; also available as tetracycline hydrochloride and tetracycline phosphate complex. Tetracycline fluorescence has been used in studies of growing tumors and calcium deposition in developing bone and teeth.

InChI: InChI=1/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1

InChIKey: InChIKey=OFVLGDICTFRJMM-WESIUVDSBE
SMILES: [H][C@@]12C[C@@]3([H])C(=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C)C(=O)C4=C(O)C=CC=C4[C@@]3(C)O

CAS number 60-54-8

Names:
    Abramycin
    Deschlorobiomycin
    Liquamycin
    Tetracycline
    tetracycline
    Tsiklomitsin
    (4S,4aS,5aS,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-

Registries:
    PubChem CID 5280962
    CAS 60-54-8 (from NIST)
    ChEBI 27902
    Kegg C06570
    PubChem ID 8799