AMILORIDE HYDROCHLORIDE

Amiloride A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)

Molecular Formula: C₆H₉Cl₂N₇O

InChI: InChI=1/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H/f/h8-11H2;

InChIKey: InChIKey=ACHKKGDWZVCSNH-LYGHNOGECE
SMILES: C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.Cl

Names:
    Amiloride chloride
    Amiloride hydrochloride anhydrous
    AMILORIDE HYDROCHLORIDE
    CCRIS 5959
    EINECS 217-958-2
    N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide monohydrochloride
    Pyrazinecarboxamide, N-amidino-3,5-diamino-6-chloro-, monohydrochloride
    2016-88-8
    2609-46-3
    3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide hydrochloride

Registries:
    PubChem CID 16230
    PubChem ID 159487