mAMSA

Amsacrine Aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.

[(Science: chemical) N-(4-(9-acridinylamino)-3-methoxyphenyl)methanesulfonamide. Aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukaemias and malignant lymphomas, but has poor activity in the treatment of solid tumours. It is frequently used in combination with other antineoplastic agent in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects. Pharmacological action: antineoplastic agent. chemical name: Methanesulfonamide, N-(4-(9-acridinylamino)-3-methoxyphenyl)-

Molecular Formula: C₂₁H₁₉N₃O₃S

InChI: InChI=1/C21H19N3O3S/c1-27-20-13-14(24-28(2,25)26)11-12-19(20)23-21-15-7-3-5-9-17(15)22-18-10-6-4-8-16(18)21/h3-13,24H,1-2H3,(H,22,23)/f/h23H

InChIKey: InChIKey=XCPGHVQEEXUHNC-MPIMZMORCD
SMILES: COc1cc(NS(C)(=O)=O)ccc1Nc2c3ccccc3nc4ccccc24

CAS number 51264-14-3

Names:
    amsacrine
    Amsacrine
    amsacrine
    mAMSA
    Methanesulfonamide, N-[4-(9-acridinylamino)-3-methoxyphenyl]-
    N-[4-(acridin-9-ylamino)-3-methoxy-phenyl]methanesulfonamide
    4'-(9-Acridinylamino)methanesulfon-meta-anisidide
    4'-(9-Acridinylamino)methanesulfon-m-anisidide
    4'-(9-Acridinylamino)methanesulphon-m-anisidide
    4'-(9-Acridinylamino)-3'-methoxymethanesulfonanilide

Registries:
    PubChem CID 2179
    Beilstein =500176
    CAS 51264-14-3 (from NIST)
    ChEBI 2687
    Kegg C01553
    PubChem ID 10476527
    PubChem ID 4711