Kortison

Cortisone A naturally occurring glucocorticoid. It has been used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent. Cortisone itself is inactive. It is converted in the liver to the active metabolite HYDROCORTISONE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p726)

[1. 17-hydroxy-11-dehydrocorticosterone, a biologically inactive adrenal corticosteroid produced by the reversible 11-hydroxylation of cortisol (17-hydroxycorticosterone). It was the first glucocorticoid to be used in therapy (1949). Like the endogenous substance, natural and synthetic cortisone administered as a drug exerts no effect until converted to cortisol.

Molecular Formula: C₂₁H₂₈O₅

InChI: InChI=1/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1

InChIKey: InChIKey=MFYSYFVPBJMHGN-ZPOLXVRWBW
SMILES: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])C(=O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

CAS number 53-06-5

Names:
    cortisone
    Cortisone
    Cortison
    cortisone
    Cortisone
    cortisone
    Kendall's compound E
    Kortison
    pregn-4-en-17α,21-diol-3,11,20-trione
    Prestwick_132
    Reichstein's substance Fa
    Wintersteiner's compound F
    Δ4-pregnene-17α,21-diol-3,11,20-trione
    (8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
    11-dehydro-17-hydroxycorticosterone
    17alpha,21-Dihydroxy-4-pregnene-3,11,20-trione
    17α,21-dihydroxy-4-pregnene-3,11,20-trione
    17-hydroxy-11-dehydrocorticosterone
    4-pregnene-17α,21-diol-3,11,20-trione
    53-06-5

Registries:
    PubChem CID 222786
    Beilstein =1356062
    CAS 53-06-5 (from NIST)
    ChEBI 16962
    Kegg C00762
    PubChem ID 10321233
    PubChem ID 4024