Nimustin

PubChem Notes:

Nimustine Antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine. The drug has also been used in combination with other antineoplastic agents or with radiotherapy for the treatment of various neoplasms.

Molecular Formula: C9H13ClN6O2


InChI: InChI=1/C9H13ClN6O2/c1-6-12-4-7(8(11)14-6)5-13-9(17)16(15-18)3-2-10/h4H,2-3,5H2,1H3,(H,13,17)(H2,11,12,14)/f/h13H,11H2

InChIKey: InChIKey=VFEDRRNHLBGPNN-VMIOWZCSCZ
SMILES: CC1=NC=C(C(=N1)N)CNC(=O)N(CCCl)N=O

Names:
    BRN 0685903
    CCRIS 2751
    EINECS 255-838-1
    Nimustina [INN-Spanish]
    Nimustine [INN]
    NIMUSTINE
    Nimustinum [INN-Latin]
    Nimustin
    1-(4-Amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea
    3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-1-(2-chloroethyl)-1-nitroso-urea
    5-25-12-00136 (Beilstein Handbook Reference)

Registries:
    PubChem CID 39214
    PubChem ID 180261