Chloramphenicol An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)
[1. An antibiotic originally obtained from Streptomyces venezuelae. It is effective against several pathogenic microorganisms. A serious reaction resulting in marrow damage with agranulocytosis or aplastic anemia may occur. Gray syndrome may occur in newborns because glucuronosyltransferase, needed to metabolize the drug, is lacking.