Primaxin

Cilastatin A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.

Molecular Formula: C₁₆H₂₅N₂NaO₅S

InChI: InChI=1/C16H26N2O5S.Na/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21;/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23);/q;+1/p-1/b12-6-;/t10-,11-;/m1./s1/fC16H25N2O5S.Na/h18,20H;/q-1;m

InChIKey: InChIKey=QXPBTTUOVWMPJN-KNUCBJSRDL
SMILES: CC1(CC1C(=O)NC(=CCCCCSCC(C(=O)O)N)C(=O)[O-])C.[Na+]

Names:
    Cilastatin sodium salt
    Cilastatin sodium [USAN:JAN]
    Cilastatin sodium
    EINECS 279-694-4
    L 642957
    MK 0791
    MK 791
    Primaxin
    sodium (Z)-7-[(2R)-2-amino-2-carboxy-ethyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoate
    2-HEPTENOIC ACID, 7-((2-AMINO-2-CARBOXYETHYL)THIO)-2-(((2,2-DIMETHYLCYCLOPROPYL)
    81129-83-1

Registries:
    PubChem CID 5282480
    PubChem ID 192214