Antramycin

Anthramycin A broad-spectrum spectrum antineoplastic antibiotic isolated from Streptomyces refuineus var. thermotolerans. It has low toxicity, some activity against Trichomonas and Endamoeba, and inhibits RNA and DNA synthesis. It binds irreversibly to DNA.

Molecular Formula: C₁₆H₁₇N₃O₄

InChI: InChI=1/C16H17N3O4/c1-8-2-4-10-13(14(8)21)18-15(22)11-6-9(3-5-12(17)20)7-19(11)16(10)23/h2-5,7,11,15,18,21-22H,6H2,1H3,(H2,17,20)/b5-3+/f/h17H2

InChIKey: InChIKey=VGQOVCHZGQWAOI-YJAKBIDVDM
SMILES: CC1=C(C2=C(C=C1)C(=O)N3C=C(CC3C(N2)O)C=CC(=O)N)O

Names:
    Anthramycin [USAN]
    ANTHRAMYCIN
    Antramicina [INN-Spanish]
    Antramycine [INN-French]
    Antramycinum [INN-Latin]
    Antramycin
    Ro 5-9000
    (E)-5,10,11,11a-Tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1H-pyrrolo(2,1-c)(1,4)-benzodiazepine-2-acrylamide
    1H-Pyrrolo(2,1-c)(1,4)benzodiazepine-2-acrylamide, 5,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-, (E)-
    4803-27-4

Registries:
    PubChem CID 5311005
    PubChem ID 163726