ANGIOTENSIN II

Angiotensin II The active form of angiotensin. An octapeptide found in blood, it is synthesized from ANGIOTENSIN I and quickly destroyed. Angiotensin II causes profound vasoconstriction with a resulting increase in blood pressure. It differs among species by the amino acid in position 5. The human form has ISOLEUCINE in this position. The clinically and experimentally used bovine form has VALINE in position 5. Medically useful antagonism is obtained with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.

Molecular Formula: C₅₇H₈₀N₁₆O₁₂

InChI: InChI=1/C57H80N16O12/c1-6-32(4)48(72-52(81)42(23-35-16-18-38(75)19-17-35)68-54(83)47(31(2)3)71-50(79)40(14-10-20-63-57(59)60)66-49(78)39(58)26-46(76)77)55(84)69-43(24-36-27-61-29-64-36)51(80)70-44(25-37-28-62-30-65-37)56(85)73-21-11-15-45(73)53(82)67-41(33(5)74)22-34-12-8-7-9-13-34/h7-9,12-13,16-19,27-32,39-45,47-48,75H,6,10-11,14-15,20-26,58H2,1-5H3,(H,61,64)(H,62,65)(H,66,78)(H,67,82)(H,68,83)(H,69,84)(H,70,80)(H,71,79)(H,72,81)(H,76,77)(H4,59,60,63)/f/h64-72,76H,59-60H2

InChIKey: InChIKey=XHCFRHASQIMAIM-QCMARAGVCS
SMILES: CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CN=CN2)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)C)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N

Names:
    ANGIOTENSIN II
    C02135
    11128-99-7
    3-amino-3-[[4-(diaminomethylideneamino)-1-[[1-[[2-(4-hydroxyphenyl)-1-[[1-[[2-(3H-imidazol-4-yl)-1-[[3-(3H-imidazol-4-yl)-1-oxo-1-[2-[(3-oxo-1-phenyl-butan-2-yl)carbamoyl]pyrrolidin-1-yl]propan-2-yl]carbamoyl]ethyl]carbamoyl]-2-methyl-butyl]carbamoyl]ethyl]carbamoyl]-2-methyl-propyl]carbamoyl]butyl]carbamoyl]propanoic acid

Registries:
    PubChem CID 439662
    PubChem ID 5214