Zoladex

Goserelin This long-acting GONADORELIN analog and agonist is used in the treatment of malignant NEOPLASMS of the prostate, uterine fibromas, and metastatic breast cancer.

[1. A synthetic decapeptide agonist analogue of LHRH (GnRH). It inhibits pituitary gonadotropin secretion and is used to treat prostate cancer, breast cancer, endometriosis, and for prethinning the endometrium before endometrial ablation or resection.

Molecular Formula: C₅₉H₈₄N₁₈O₁₄

InChI: InChI=1/C59H84N18O14/c1-31(2)22-40(49(82)68-39(12-8-20-64-57(60)61)56(89)77-21-9-13-46(77)55(88)75-76-58(62)90)69-54(87)45(29-91-59(3,4)5)74-50(83)41(23-32-14-16-35(79)17-15-32)70-53(86)44(28-78)73-51(84)42(24-33-26-65-37-11-7-6-10-36(33)37)71-52(85)43(25-34-27-63-30-66-34)72-48(81)38-18-19-47(80)67-38/h6-7,10-11,14-17,26-27,30-31,38-46,65,78-79H,8-9,12-13,18-25,28-29H2,1-5H3,(H,63,66)(H,67,80)(H,68,82)(H,69,87)(H,70,86)(H,71,85)(H,72,81)(H,73,84)(H,74,83)(H,75,88)(H4,60,61,64)(H3,62,76,90)/f/h66-76H,60-62H2

InChIKey: InChIKey=BLCLNMBMMGCOAS-LMKYEUCVCQ
SMILES: CC(C)CC(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NNC(=O)N)NC(=O)C(COC(C)(C)C)NC(=O)C(CC2=CC=C(C=C2)O)NC(=O)C(CO)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CN=CN5)NC(=O)C6CCC(=O)N6

Names:
    Decapeptide I
    D-Ser(t-Bu)(sup 6)aza-gly(sup 10)-GNRH
    Goserelina [Spanish]
    Gosereline [French]
    Goserelinum [Latin]
    Goserelin acetate
    Goserelin [USAN:BAN:INN]
    goserelin
    ICI 118630
    N-[1-[[1-[[1-[[1-[[1-[[1-[[1-[2-[(carbamoylamino)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxo-pentan-2-yl]carbamoyl]-3-methyl-butyl]carbamoyl]-2-[(2-methylpropan-2-yl)oxy]ethyl]carbamoyl]-2-(4-hydroxyphenyl)ethyl]carbamoyl]-2-hydroxy-ethyl]carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl]-2-(3H-imidazol-4-yl)ethyl]-5-oxo-pyrrolidine-2-carboxamide
    Zoladex

Registries:
    PubChem CID 47725
    PubChem ID 186963