L-glutamic acid, monosodium salt
Hydrolyzed vegetable protein
White crystalline powder.
MSG is the sodium salt of the amino acid glutamic acid.
It is made commercially by the fermentation of molasses, but exists in many products made from fermented proteins, such as soy sauce and hydrolyzed vegetable protein.
The tongue is sensitive to five flavors -- salt, sweet, bitter, sour, and umami, the taste of MSG.
Glutamic acid is a component of many proteins, such as those in dairy products, meat, legumes, and mushrooms. However, only the free form of glutamic acid or glutamates has an effect on the glutamate receptors. When bound to other amino acids in a protein, it does not stimulate glutamate receptors.
Free glutamate exists in certain cheeses (such as parmesan), in tomato products, and in soy sauce. These products are often used to enhance the flavor of meat dishes.
Proteins can be hydrolyzed by heat, releasing free glutamates. Cooked meats, especially grilled meats, get some of their taste from free glutamates.
MSG is used to give a "meaty", "savory", or "brothy" taste to foods by stimulating the glutamate receptors on the tongue.
There are glutamate receptors in other parts of the body, notably the brain, where glutamate is a neurotransmitter.
Glutamates can be produced by fermentation of starches or sugars, but also by breaking the bonds between amino acids in proteins, leaving free amino acids. This process is done by heat or by enzymes, and is called hydrolyzing because the bonds are broken by adding water.
When proteins are broken down into their constituent amino acids, the result can contain as much as 20 percent glutamates. This is why hydrolyzed vegetable protein is often listed as an ingredient in foods, to give them a meaty or savory flavor.
There is evidence that some people are sensitive to free glutamates, and may get headaches or other symptoms if too much is ingested. This may be related to pyridoxine (vitamin B6) deficiencies, as this vitamin is necessary for glutamate metabolism. People with uncontrolled severe asthma may find that it complicates or worsens their symptoms.
Bound glutamates in proteins are very common in food. Human breast milk contains ten times as much as cow's milk, and tomato juice contains 4 times as much as breast milk. However, free glutamate, as found in soy sauce or prepared foods, enters the bloodstream much faster than the glutamates bound in proteins, where they are released slowly during digestion.
monosodium glutamate: InChI=1/C5H9NO4.Na.H2O/c6-3(5(9)10)1-2-4(7)8;;/h3H,1-2,6H2,(H,7,8)(H,9,10);;1H2/q;+1;/p-1/t3-;;/m0../s1/fC5H8NO4.Na.H2O/h9H;;/q-1;m;