Diamox

[(Science: chemical) a carbonic anhydrase inhibitor that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. however, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. Pharmacological action: anticonvulsants, carbonic anhydrase inhibitors, diuretics. chemical name: Acetamide, N-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)-

[1. The heterocyclic sulfonamide 5-acetylamido-1,3,4-thiadiazole-2-sulfonamide, which inhibits the action of carbonic anhydrase in the kidney, increasing the urinary excretion of sodium, potassium, and bicarbonate, reducing excretion of ammonium, raising the pH of the urine, and lowering the pH of the blood; used in respiratory acidosis for diuresis and to stimulate respiratory drive, in glaucoma to reduce intraocular pressure, and in epilepsy.

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Molecular Formula: C₄H₆N₄O₃S₂

InChI: InChI=1/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)/f/h6H,5H2

InChIKey: InChIKey=BZKPWHYZMXOIDC-WQDBGGICCO
SMILES: CC(=O)Nc1nnc(s1)S(N)(=O)=O

CAS number 59-66-5

Names:
    Acetazolamide
    acetazolamide
    Diamox
    KBio3_001288
    N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
    N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide
    N-[5-(aminosulfonyl)-1,3,5-thiadiazol-2-yl]acetamide
    2-acetylamino-1,3,4-thiadiazole-5-sulfonamide
    5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE
    5-acetylamino-1,3,4-thiadiazole-2-sulfonamide

Registries:
    ChemSpider: InChIKey=BZKPWHYZMXOIDC-WQDBGGICCO
    PubChem CID 1986
    Beilstein =212994
    CAS 59-66-5 (from NIST)
    ChEBI 27690
    chemPDB AZM
    Gmelin 365421
    Kegg C06805
    PubChem ID 11371388
    PubChem ID 9024

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